CMI-392


Catalog No. Size PriceQuantity
M21850-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.

Product information

CAS Number: 205654-37-1

Molecular Weight: 633.15

Formula: C31H37ClN2O8S

Chemical Name: 1-[(2-{2-[(4-chlorophenyl)sulfanyl]ethoxy}-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl)methyl]-3-hydroxy-3-methylurea

Smiles: CN(O)C(=O)NCC1=CC(=CC(OC)=C1OCCSC1C=CC(Cl)=CC=1)[C@@H]1CC[C@H](O1)C1=CC(OC)=C(OC)C(=C1)OC

InChiKey: LZVBMKDVEPGGFK-DQEYMECFSA-N

InChi: InChI=1S/C31H37ClN2O8S/c1-34(36)31(35)33-18-21-14-19(15-26(37-2)29(21)41-12-13-43-23-8-6-22(32)7-9-23)24-10-11-25(42-24)20-16-27(38-3)30(40-5)28(17-20)39-4/h6-9,14-17,24-25,36H,10-13,18H2,1-5H3,(H,33,35)/t24-,25-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Topical treatment of CMI-392 in the acute and chronic TPA models result in a significant decrease of ear weight, inflammatory cell infiltration, and histological examination. The ED50 for PAF-induced mouse hemoconcentration and arachidonic acid-induced mouse ear edema are 2.2 and 1.8 mg/kg, respectively.

Products are for research use only. Not for human use.

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