L-Aspartic acid


Catalog No. Size PriceQuantity
M21878-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

Product information

CAS Number: 56-84-8

Molecular Weight: 133.10

Formula: C4H7NO4

Chemical Name: (2S)-2-aminobutanedioic acid

Smiles: N[C@@H](CC(O)=O)C(O)=O

InChiKey: CKLJMWTZIZZHCS-REOHCLBHSA-N

InChi: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 8.33 mg/mL (62.58 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu.

Products are for research use only. Not for human use.

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