Epertinib hydrochloride

Catalog No. Size PriceQuantity
M21970-C Contact sales@xcessbio.com for quotation $100Unavailable


Epertinib hydrochloride (S-22611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride shows potent antitumor activity.

Product information

CAS Number: 2071195-74-7

Molecular Weight: 596.48

Formula: C30H28Cl2FN5O3

Chemical Name: N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-[(1Z)-1-({[(3R)-morpholin-3-yl]methoxy}imino)but-2-yn-1-yl]quinazolin-4-amine hydrochloride

Smiles: Cl.CC#C/C(=N\OC[C@H]1COCCN1)/C1=CC2C(C=C1)=NC=NC=2NC1=CC=C(OCC2C=C(F)C=CC=2)C(Cl)=C1


InChi: InChI=1S/C30H27ClFN5O3.ClH/c1-2-4-27(37-40-18-24-17-38-12-11-33-24)21-7-9-28-25(14-21)30(35-19-34-28)36-23-8-10-29(26(31)15-23)39-16-20-5-3-6-22(32)13-20;/h3,5-10,13-15,19,24,33H,11-12,16-18H2,1H3,(H,34,35,36);1H/b37-27+;/t24-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (209.56 mM; Need ultrasonic). H2O : 33.33 mg/mL (55.88 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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