Apogossypolone (ApoG2)


Catalog No. Size PriceQuantity
M21997-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Apogossypolone is an inhibitor of Bcl-2, Mcl-1 and Bcl-XL with Ki values of 35nM, 25nM and 660nM, respectively . The MTT-based cell cytotoxicity assay shows that apogossypolone has an anticancer activity with IC50 values of 1, 2 and 3μM, respectively in PC-3, DU-145 (human prostate cancer cell lines) and MDA-MB-231(human breast cancer cell line). Apogossypolone is also found to inhibit the colony formation of DU-145 cells. The mechanism is that apogossypolone binds to Bcl-2 and prevents its association with BH3-only pro-apoptotic proteins, leading the pro-apoptotic proteins to participate in the apoptotic response . Besides prostate cancer and breast cancer, apogossypolone is also potent in follicular lymphoma. Apogossypolone significantly inhibits the cell growth via inducing apoptosis in WSU-FSCCL cell line with IC50 value of 109.2nM at 72h .

Product information

CAS Number: 886578-07-0

Molecular Weight: 490.50

Formula: C28H26O8

Chemical Name: 1,1',4,4'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(propan-2-yl)-6H,6'H,7H,7'H-[2,2'-binaphthalene]-6,6',7,7'-tetrone

Smiles: CC1C(C2=C(O)C3=CC(=O)C(=O)C(C(C)C)=C3C(O)=C2C)=C(O)C2=CC(=O)C(=O)C(C(C)C)=C2C=1O

InChiKey: JOVVKPCDUDNVPP-UHFFFAOYSA-N

InChi: InChI=1S/C28H26O8/c1-9(2)17-21-13(7-15(29)27(17)35)25(33)19(11(5)23(21)31)20-12(6)24(32)22-14(26(20)34)8-16(30)28(36)18(22)10(3)4/h7-10,31-34H,1-6H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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