PK 44 phosphate

Catalog No. Size PriceQuantity
M22386-C Contact for quotation $100Unavailable


PK 44 phosphate Description:IC50: 15.8 nm (DPP-IV) The protein encoded by the DPP4 gene is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. Inhibitors of dipeptidyl peptidase 4, also DPP-4 inhibitors or gliptins, are a class of oral hypoglycemics that block DPP-4. They can be used to treat diabetes mellitus type 2 ( PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV). In vitro: With a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), PK 44 phosphate showed more than 1000-fold selectivity for DPP-IV over DPP-8 and DPP-9 . In vivo: PK 44 phosphate was found to be able to improve glucose tolerance in a mouse oral glucose tolerance assay . Clinical trial: PK 44 phosphate is currently in the preclinical development and no clinical trial is ongoing.

Product information

CAS Number: 1017682-65-3

Molecular Weight: 527.34

Formula: C17H19F5N7O5P

Chemical Name: (3R)-3-amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one; phosphoric acid

Smiles: N[C@@H](CC(=O)N1CC2=NN=C(N2CC1)C(F)(F)F)CC1=NNC2=C1C=CC(F)=C2F.OP(O)(O)=O


InChi: InChI=1S/C17H16F5N7O.H3O4P/c18-10-2-1-9-11(24-26-15(9)14(10)19)5-8(23)6-13(30)28-3-4-29-12(7-28)25-27-16(29)17(20,21)22;1-5(2,3)4/h1-2,8H,3-7,23H2,(H,24,26);(H3,1,2,3,4)/t8-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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