Description
6-methoxy Naphthalene Acetic Acid is a competitive and non-selective COX inhibitor with Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively . Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, PGHS), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. COX-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (GI) and of the proaggregatory thromboxane in blood platelets. COX-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. COX-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system . 6-methoxy Naphthalene Acetic Acid (6-MNA) is a competitive and non-selective COX inhibitor with Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively . 6-MNA is a metabolite of nebumetome. 6-MNA inhibited human recombinant COX-1 and -2 with IC50 values of 70 and 20 μM, respectively .
Product information
CAS Number: 23981-47-7
Molecular Weight: 216.23
Formula: C13H12O3
Chemical Name: 2-(6-methoxynaphthalen-2-yl)acetic acid
Smiles: COC1=CC2=CC=C(CC(O)=O)C=C2C=C1
InChiKey: PHJFLPMVEFKEPL-UHFFFAOYSA-N
InChi: InChI=1S/C13H12O3/c1-16-12-5-4-10-6-9(7-13(14)15)2-3-11(10)8-12/h2-6,8H,7H2,1H3,(H,14,15)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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