1, 3-PBIT (dihydrobromide)


Catalog No. Size PriceQuantity
M22529-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

1,3-PBIT (dihydrobromide) is a potent and selective iNOS inhibitor with Ki value of 47 nM . Nitric oxide (NO) is an endogenously produced inorganic free radical gas which has been implicated in blood pressure homeostasis, platelet aggregation, neurotransmission, and immunological defense mechanisms. NO is synthesized by three isoforms of nitric oxide synthase (NOS): nNOS, eNOS and iNOS . 1,3-PBIT, also known as S,S’-(1,3-Phenylenebis(1,2-ethanediyl))bisisothiourea, is a potent and selective iNOS inhibitor. 1,3-PBIT inhibited purified human iNOS, eNOS and nNOS with Ki values of 47 nM, 9 μM and 0.25 μM, respectively. 1,3-PBIT exhibited 190-fold selective against iNOS versus eNOS. In DLD-1 cells, 1,3-PBIT inhibited human iNOS with IC50 value of 150 μM, presumably to poor membrane permeability . In conscious male Sprague-Dawley rats, 1,3-PBIT (10mg/kg, ip; 1 h after endotoxin) inhibited endotoxin-induced decrease in MAP, renal CYP 4A1/A3 protein level and CYP 4A activity and increase in systemic and renal nitrite production .

Product information

CAS Number: 200716-66-1

Molecular Weight: 444.25

Formula: C12H20Br2N4S2

Chemical Name: N'-hydrogenio{[2-(3-{2-[(N'-hydrogeniocarbamimidoyl)sulfanyl]ethyl}phenyl)ethyl]sulfanyl}methanimidamide dihydrobromide

Smiles: Br.Br.[H]/N=C(\N)/SCCC1C=C(CCS/C(/N)=N\[H])C=CC=1

InChiKey: WCXGFTJSDASEPR-UHFFFAOYSA-N

InChi: InChI=1S/C12H18N4S2.2BrH/c13-11(14)17-6-4-9-2-1-3-10(8-9)5-7-18-12(15)16;;/h1-3,8H,4-7H2,(H3,13,14)(H3,15,16);2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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