Description
AG-183, a member of tyrphostin, is an inhibitor of protein tyrosine kinase . Protein tyrosine kinase is an enzyme that catalyzes the transfer of the γ phosphate of ATP to tyrosine residues on protein substrates. Phosphorylation of proteins by kinases is an important mechanism in signal transduction and regulating cellular activity, such as cell division. Tyrosine phosphorylation is a key covalent modification that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. Phosphorylation of tyrosine residues modulates enzymatic activity and creates binding sites for the recruitment of downstream signaling proteins . PTK inhibitors could preferentially inhibit the epidermal growth factor (EGF) receptor kinase to block EGF-dependent cell proliferation . In the human epidermoid carcinoma cell line, A431AG-183 inhibited the activity of epidermal growth factor (EGF) receptor kinase with an IC50 value of 800 nM .
Product information
CAS Number: 122520-90-5
Molecular Weight: 268.23
Formula: C13H8N4O3
Chemical Name: (3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methylidene]prop-1-ene-1,1,3-tricarbonitrile
Smiles: NC(=C(C#N)C#N)/C(=C/C1=CC(O)=C(O)C(O)=C1)/C#N
InChiKey: JKNOYWVMHPMBEL-UNXLUWIOSA-N
InChi: InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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