Catalog No. Size PriceQuantity
M22650-C Contact for quotation $100Unavailable


Resistomycin is a natural antibiotic. Resistomycin is a natural antibiotic produced by several actinobacteriae, such as Streptomyces. In vitro: Resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of Streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of Hypericum perforatum L. as modulators for apoptosis. In human megakaryoblastic leukemia CMK-7 cells, resistomycin could inhibit apoptosis induced by actinomycin D (AD) with or without acceleration by colcemid (CL), IC50 for inhibition against AD-induced apoptosis was about 0.5 μM and IC50 for inhibition against AD plus CL-induced apoptosis was about 1 μM. CL alone induced weak apoptosis in cells, which could be enhanced by resistomycin. Moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. In addition, PKC in CMK-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.

Product information

CAS Number: 20004-62-0

Molecular Weight: 376.36

Formula: C22H16O6

Chemical Name: 2,4,10,14-tetrahydroxy-7,7,12-trimethylpentacyclo[⁵,¹⁸.0⁸,¹⁷.0¹¹,¹⁶]nonadeca-1,3,5(18),8(17),9,11,13,15-octaene-6,19-dione

Smiles: CC1C=C(O)C2=C3C=1C(O)=CC1=C3C3C(C2=O)=C(O)C=C(O)C=3C(=O)C1(C)C


InChi: InChI=1S/C22H16O6/c1-7-4-9(23)15-18-13(7)10(24)5-8-14(18)19-16(20(15)27)11(25)6-12(26)17(19)21(28)22(8,2)3/h4-6,23-26H,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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