Description
IC50: N/A 1-Oleoyl lysophosphatidic acid (LPA) is a naturally occurring phospholipid with various effects. LPA is widely distributed in many tissues. Similar to many other biomediators, LPA interacts with cells via specific cell surface receptors, such as G proteincoupled receptors, to induce biological effects. In vitro: LPA could mediate signal transduction via Edg/LPA receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. Additionally, LPA was found to elicit upregulation of VEGF, leading to an indirect influence on initiation and progression of malignancies. LPA could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor . In vivo: LPA was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. Serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the LPA receptor 1 and 3 antagonists. LPA also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of LPA receptor 1 or 3 . Clinical trial: Clinical retults showed that LPA concentration was significantly higher in pancreatic cancer patients. For diagnosis of pancreatic cancer, the sensitivity of LPA was 89.6% and the specificity 79. 4%. However, plasma LPA alteration had shown significant correlations with the tumor size, pathological stage, surrounding lymph nodes, as well as specific histopathological features .
Product information
CAS Number: 325465-93-8
Molecular Weight: 458.50
Formula: C21H40NaO7P
Chemical Name: sodium (2R)-3-(hydrogen phosphonatooxy)-2-hydroxypropyl (9Z)-octadec-9-enoate
Smiles: [Na+].CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP([O-])(O)=O
InChiKey: XGRLSUFHELJJAB-JGSYTFBMSA-M
InChi: InChI=1S/C21H41O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);/q;+1/p-1/b10-9-;/t20-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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