Butenoyl PAF


Catalog No. Size PriceQuantity
M22726-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Butenoyl PAF is a PAF receptor agonist . Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock . Butanoyl-PAF and Butenoyl PAF are both products of the oxidative decomposition of 2-arachidonoyl phospholipids. Although Butenoyl PAF is 10-fold less potent than PAF as a PAF receptor agonist and ligand, it is 100-fold more abundant in oxidized LDL than PAF. Therefore, oxidation products of LDL phospholipids were physiologically relevant bioactive PAF-like molecules .

Product information

CAS Number: 474944-25-7

Molecular Weight: 549.72

Formula: C28H56NO7P

Chemical Name: (2-{[(2R)-2-[(2E)-but-2-enoyloxy]-3-(hexadecyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium

Smiles: C/C=C/C(=O)O[C@H](COCCCCCCCCCCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)C

InChiKey: SRZBVCCSIMMDOV-UUUXUCBLSA-N

InChi: InChI=1S/C28H56NO7P/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-20-23-33-25-27(36-28(30)21-7-2)26-35-37(31,32)34-24-22-29(3,4)5/h7,21,27H,6,8-20,22-26H2,1-5H3/b21-7+/t27-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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