BW A868C


Catalog No. Size PriceQuantity
M22728-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BW A868C is a novel, selective and potent competitive antagonist of prostaglandin D2 (PGD2) . Prostaglandin D2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system . Prostaglandin D2 is critical for the development of allergic diseases such as asthma. In vitro: In glycerol-lysed human platelets, BW245C activated adenylate cyclase in a biphasic manner. BW A868C showed no effect on carbacyclin, iloprost, prostacyclin, PGE1 and PGE2 at a concentration 1,000 fold that of its KB against PGD2 and BW245C . BW A868C showed no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki value for BW A868C is approximately 1.7 nM .In isolated rings of rabbit saphenous vein (RbSV) pre-contracted with 40 mM KCl, BW245C caused concentration-dependent relaxations with an EC50 of 38 nM .

Product information

CAS Number: 118675-50-6

Molecular Weight: 459.58

Formula: C25H37N3O5

Chemical Name: 7-{1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl}heptanoic acid

Smiles: OC(=O)CCCCCCC1C(=O)N(CC2C=CC=CC=2)C(=O)N1NCC(O)C1CCCCC1

InChiKey: YZJVWSKJHGEIBL-UHFFFAOYSA-N

InChi: InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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