Description
ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac . Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation . Oral administration of ATB-337 did not produce any hemorrhagic erosions. Oral administration of an equimolar dose of ATB-337 produced > 90% less small intestinal damage and showed no significant effect on the hematocrit. In rats, administration of ATB-337 (50 μmol/kg) showed no significant effect on leukocyte adherence. Oral administration of ATB-337 significantly increased plasma levels of H2S by > 40%. In a rat air pouch model, ATB-337 (1 μmol/kg) suppressed COX-2 activity. In the rat, ATB-337 inhibited thromboxane synthesis. ATB-337 suppressed arachidonic acid–induced human platelet aggregation. Pretreatment with ATB-337 (10 μmol/kg) reduced paw swelling. ATB-337 generated ～12nmol/min of H2S when it was incubated in buffer.
Product information
CAS Number: 912758-00-0
Molecular Weight: 504.47
Formula: C23H15Cl2NO2S3
Chemical Name: 4-(3-sulfanylidene-3H-1,2-dithiol-5-yl)phenyl 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetate
Smiles: O=C(CC1=CC=CC=C1NC1C(Cl)=CC=CC=1Cl)OC1C=CC(=CC=1)C1=CC(=S)SS1
InChiKey: BRDUXOHVEZVAHI-UHFFFAOYSA-N
InChi: InChI=1S/C23H15Cl2NO2S3/c24-17-5-3-6-18(25)23(17)26-19-7-2-1-4-15(19)12-21(27)28-16-10-8-14(9-11-16)20-13-22(29)31-30-20/h1-11,13,26H,12H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.