GNF351


Catalog No. Size PriceQuantity
M22806-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes.IC50: 62 nM (aryl hydrocarbon receptor) GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes. Cell Proliferation Assay Cell Line: Human primary keratinocytes . van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.

Product information

CAS Number: 1227634-69-6

Molecular Weight: 411.50

Formula: C24H25N7

Chemical Name: N-[2-(1H-indol-3-yl)ethyl]-2-(5-methylpyridin-3-yl)-9-(propan-2-yl)-9H-purin-6-amine

Smiles: CC1C=C(C=NC=1)C1N=C2C(N=CN2C(C)C)=C(NCCC2=CNC3C=CC=CC=32)N=1

InChiKey: ABXIUYMKZDZUDC-UHFFFAOYSA-N

InChi: InChI=1S/C24H25N7/c1-15(2)31-14-28-21-23(26-9-8-17-13-27-20-7-5-4-6-19(17)20)29-22(30-24(21)31)18-10-16(3)11-25-12-18/h4-7,10-15,27H,8-9H2,1-3H3,(H,26,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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