Description
IC50: 0.8-1.5 nM for rat and human 5-HT2 receptor AL 34662 is a potent 5-HT2 receptor agonist. SEROTONIN (5-hydroxytryptamine; 5-HT) is a major neurotransmitter in the central nervous system (CNS) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs. In vitro: AL-34662 exhibited a high affinity for the rat and human 5-HT2 receptor and for cloned human 5-HT2A-C receptors. AL-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. AL-34662 also mobilized intracellular Ca2+ in h-CM and h-TM cells, being a full agonist like 5-HT itself. AL-34662's effects in the h-CM cells were potently antagonized by 5-HT2A-antagonist M-100907, but weakly by 5-HT2B-antagonist, 5-HT2B/C- antagonist and 5-HT2C antagonist. Moreover, it was found that the (R)-enantiomer (AL-34707) and the racemate (AL-34497) were less potent and/or efficacious than AL-34662 in all of these assays . In vivo: AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. It efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes . Clinical trial: So far, no clinical study has been conducted.
Product information
CAS Number: 210580-75-9
Molecular Weight: 191.23
Formula: C10H13N3O
Chemical Name: 1-[(2R)-2-aminopropyl]-1H-indazol-6-ol
Smiles: C[C@@H](N)CN1N=CC2=CC=C(O)C=C12
InChiKey: WBYHTZYHAFNBKW-SSDOTTSWSA-N
InChi: InChI=1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,14H,6,11H2,1H3/t7-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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