Description
M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay. M50054 inhibited the apoptotic U937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. M50054 inhibited apoptotic characters such as DNA phosphatidylserine and fragmentation exposure in these cells. These anti-apoptotic effects were dependent on inhibition of caspase-3 activation. Additionally, M50054 significantly inhibited anti-Fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. Alopecia (hair loss) symptoms were also significantly improved with topical treatment with M50054. M50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia.
Product information
CAS Number: 54135-60-3
Molecular Weight: 236.26
Formula: C13H16O4
Chemical Name: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
Smiles: O=C1CCCC(=O)C1CC1C(=O)CCCC1=O
InChiKey: ILUMEPMGPCKGHH-UHFFFAOYSA-N
InChi: InChI=1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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