Epidermal growth factor receptor (994-1002) acetyl/amide

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 inhumans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands1. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor ǁ (TGFǁ). Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme2. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Mutations involving EGFR could lead to its constant activation, which could result in uncontrolled cell division - a predisposition for cancer. Consequently, mutations of EGFR have been identified in several types of cancer, and it is the target of an expanding class of anticancer therapies3.

Product information

Molecular Weight: 1157.30

Formula: C51H76N14O15S

Chemical Name: 3-[(1-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[(1-{[1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]ethyl}carbamoyl)butyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-carbamoylethyl]carbamoyl}-2-hydroxyethyl)carbamoyl]-3-acetamidopropanoic acid

Smiles: CC(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC1C=CC=CC=1)C(=O)NC(CC1C=CC(O)=CC=1)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O

InChiKey: SCMAKVKGJZYBIE-UHFFFAOYSA-N

InChi: InChI=1S/C51H76N14O15S/c1-26(2)20-34(45(75)59-32(42(53)72)17-19-81-5)61-43(73)27(3)57-44(74)33(12-9-18-56-51(54)55)60-46(76)36(22-30-13-15-31(68)16-14-30)62-47(77)35(21-29-10-7-6-8-11-29)63-48(78)37(23-40(52)69)64-50(80)39(25-66)65-49(79)38(24-41(70)71)58-28(4)67/h6-8,10-11,13-16,26-27,32-39,66,68H,9,12,17-25H2,1-5H3,(H2,52,69)(H2,53,72)(H,57,74)(H,58,67)(H,59,75)(H,60,76)(H,61,73)(H,62,77)(H,63,78)(H,64,80)(H,65,79)(H,70,71)(H4,54,55,56)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.