CPTH2 (hydrochloride)


Catalog No. Size PriceQuantity
M23394-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CPTH2 is an inhibitor of HAT activity of Gcn5. Histone acetyltransferases (HATs) has been identified to add the acetyl group on the specific lysine of histone H3 and H4 N-termini, and such signatures are able to increase the accessibility of the underlying chromatin at specific genes or over vast regions of the genome. Gcn5p is a chimeric protein made up of a number of functional domains. In vitro: Previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reverted by increasing concentration of histone H3 . In vivo: In vivo, CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site . Clinical trial: Up to now, CPTH2 is still in the preclinical development stage.

Product information

Molecular Weight: 328.26

Formula: C14H15Cl2N3S

Chemical Name: 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazin-1-yl)-1,3-thiazole hydrochloride

Smiles: Cl.ClC1=CC=C(C=C1)C1=CSC(NN=C2CCCC2)=N1

InChiKey: ODVWZAKKCNHATB-UHFFFAOYSA-N

InChi: InChI=1S/C14H14ClN3S.ClH/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12;/h5-9H,1-4H2,(H,16,18);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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