Angiotensin 1/2 (5-7)


Catalog No. Size PriceQuantity
M23396-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system1. Angiotensin I is formed by the action of renin on angiotensinogen. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure at the juxtaglomerular cells2, or decreased delivery of Na+ and Cl- to the macula densa3.If less Na+ is sensed by the macula densa, renin release by juxtaglomerular cells is increased.Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide (des-Asp) angiotensin I Angiotensin I appears to have no biological activity and exists solely as a precursor to angiotensin 2.

Product information

Molecular Weight: 365.43

Formula: C17H27N5O4

Chemical Name: (2R)-1-[(2S)-2-[(2S,3R)-2-amino-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid

Smiles: C[C@H](CC)[C@H](N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@@H]1C(O)=O

InChiKey: LNJLOZYNZFGJMM-CABNGKKXSA-N

InChi: InChI=1S/C17H27N5O4/c1-3-10(2)14(18)15(23)21-12(7-11-8-19-9-20-11)16(24)22-6-4-5-13(22)17(25)26/h8-10,12-14H,3-7,18H2,1-2H3,(H,19,20)(H,21,23)(H,25,26)/t10-,12+,13-,14+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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