CDK ligand for PROTAC hydrochloride

Catalog No. Size PriceQuantity
M23425-C Contact for quotation $100Unavailable


CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. CDK ligand for PROTAC hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader. . Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.

Product information

Molecular Weight: 531.00

Formula: C25H29ClF2N8O

Chemical Name: {4-fluoro-6-[5-fluoro-2-({5-[(piperazin-1-yl)methyl]pyridin-2-yl}amino)pyrimidin-4-yl]-1-(propan-2-yl)-1H-1,3-benzodiazol-2-yl}methanol hydrochloride

Smiles: Cl.CC(C)N1C(CO)=NC2=C1C=C(C=C2F)C1=NC(NC2C=CC(CN3CCNCC3)=CN=2)=NC=C1F


InChi: InChI=1S/C25H28F2N8O.ClH/c1-15(2)35-20-10-17(9-18(26)24(20)32-22(35)14-36)23-19(27)12-30-25(33-23)31-21-4-3-16(11-29-21)13-34-7-5-28-6-8-34;/h3-4,9-12,15,28,36H,5-8,13-14H2,1-2H3,(H,29,30,31,33);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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