IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]


Catalog No. Size PriceQuantity
M23452-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. IgM is expressed on the surface of B cells (monomer) and in a secreted form (pentamer) with very high avidity. Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient IgG. The immunoglobulin light chain is the small polypeptide subunit of an antibody ( immunoglobulin). Kappa (NJ) chain, one of the two types of light chain in mammals, is encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2. Only V and J segments are found in Ig light chains. The approximate length of a light chain protein is from 211 to 217 amino acids. If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma. Increased levels of free Ig light chains have also been detected in various inflammatory diseases. Very recent studies have shown that Ig light chains not only activate mast cells but also dorsal root ganglia (Rijnierse, 2009)) and neutrophils (Braber and Thio (2012)), expanding their possible role as mediators in inflammatory disease.

Product information

Molecular Weight: 809.90

Formula: C37H59N7O13

Chemical Name: (2R,3S)-2-[(2S,3S)-2-{2-[(2S,3S)-2-(2-{2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-carboxypropanamido}-3-phenylpropanamido)-3-hydroxybutanamido]-4-methylpentanamido}-3-hydroxybutanamido]-3-methylpentanoic acid

Smiles: CC(C)CC(NC(=O)[C@@H](NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)[C@H](C)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@H]([C@@H](C)CC)C(O)=O

InChiKey: ZDCOFXJMPYECMR-WZBTXJROSA-N

InChi: InChI=1S/C37H59N7O13/c1-8-18(4)28(37(56)57)42-36(55)30(21(7)47)44-32(51)23(14-17(2)3)41-35(54)29(20(6)46)43-33(52)24(15-22-12-10-9-11-13-22)39-31(50)25(16-26(48)49)40-34(53)27(38)19(5)45/h9-13,17-21,23-25,27-30,45-47H,8,14-16,38H2,1-7H3,(H,39,50)(H,40,53)(H,41,54)(H,42,55)(H,43,52)(H,44,51)(H,48,49)(H,56,57)/t18-,19+,20-,21-,23?,24?,25?,27-,28+,29-,30-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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