Bobcat339


Catalog No. Size PriceQuantity
M23594-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.

Product information

CAS Number: 2280037-51-4

Molecular Weight: 297.74

Formula: C16H12ClN3O

Chemical Name: 4-amino-1-{[1,1'-biphenyl]-3-yl}-5-chloro-1,2-dihydropyrimidin-2-one

Smiles: NC1=NC(=O)N(C=C1Cl)C1=CC(=CC=C1)C1C=CC=CC=1

InChiKey: QMGYGOOYCNTEQO-UHFFFAOYSA-N

InChi: InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.

Products are for research use only. Not for human use.

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