Rubropunctatin


Catalog No. Size PriceQuantity
M23712-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.

Product information

CAS Number: 514-67-0

Molecular Weight: 354.40

Formula: C21H22O5

Chemical Name: (9aR)-3-hexanoyl-9a-methyl-6-[(1E)-prop-1-en-1-yl]-2H,9H,9aH-furo[3,2-g]isochromene-2,9-dione

Smiles: C/C=C/C1=CC2=CC3=C(C(=O)O[C@@]3(C)C(=O)C2=CO1)C(=O)CCCCC

InChiKey: SULYDLFVUNXAMP-WKOQKXSESA-N

InChi: InChI=1S/C21H22O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10-12H,4,6-7,9H2,1-3H3/b8-5+/t21-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1. Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells. Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.

In Vivo:

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice. Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear.

Products are for research use only. Not for human use.

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