Apremilast D5


Catalog No. Size PriceQuantity
M23722-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.

Product information

CAS Number: 1258597-47-5

Molecular Weight: 465.53

Formula: C22H24N2O7S

Chemical Name: N-{2-[(1S)-1-{3-[(1,1,2,2,2-²H₅)ethoxy]-4-methoxyphenyl}-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Smiles: [2H]C([2H])([2H])C([2H])([2H])OC1=CC(=CC=C1OC)[C@@H](CS(C)(=O)=O)N1C(=O)C2C(=CC=CC=2NC(C)=O)C1=O

InChiKey: IMOZEMNVLZVGJZ-JVFKXMKASA-N

InChi: InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1/i1D3,5D2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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