p-MPPI hydrochloride

Catalog No. Size PriceQuantity
M23768-C Contact sales@xcessbio.com for quotation $100Unavailable


p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.

Product information

CAS Number: 220643-77-6

Molecular Weight: 578.87

Formula: C25H28ClIN4O2

Chemical Name: 4-iodo-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)benzamide hydrochloride

Smiles: Cl.COC1=CC=CC=C1N1CCN(CCN(C(=O)C2C=CC(I)=CC=2)C2=CC=CC=N2)CC1


InChi: InChI=1S/C25H27IN4O2.ClH/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20;/h2-13H,14-19H2,1H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 17.86 mg/mL (30.85 mM; Need ultrasonic). H2O : 3.33 mg/mL (5.75 mM; ultrasonic and warming and heat to 60°C).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity.

In Vivo:

p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze.

Products are for research use only. Not for human use.

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