LC3-mHTT-IN-AN2


Catalog No. Size PriceQuantity
M23863-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

Product information

CAS Number: 7758-73-8

Molecular Weight: 254.24

Formula: C15H10O4

Chemical Name: 5,7-dihydroxy-4-phenyl-2H-chromen-2-one

Smiles: OC1=CC(O)=CC2OC(=O)C=C(C1=2)C1C=CC=CC=1

InChiKey: HUQKUJNSVHEHIH-UHFFFAOYSA-N

InChi: InChI=1S/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (983.32 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

LC3-mHTT-IN-AN2 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.

Products are for research use only. Not for human use.

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