Description
ALK-IN-9 (compound 40) is a potent ALK inhibitor. ALK-IN-9 inhibits cell proliferation with IC50s of <0.2 nM, <0.2 nM, 0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), KG-l cell (OP2-FGFR1), respectively.
Product information
CAS Number: 2359662-39-6
Molecular Weight: 412.42
Formula: C20H21FN6O3
Chemical Name: (18R)-13-fluoro-7,7,18-trimethyl-9,20-dioxa-1,2,6,11,17,23-hexaazapentacyclo[19.3.1.0⁴,²⁴.0¹⁰,¹⁵.0¹⁷,²²]pentacosa-2,4(24),10,12,14,21(25),22-heptaen-5-one
Smiles: C[C@@H]1COC2=CN3N=CC4C(=O)NC(C)(C)COC5=NC=C(F)C=C5CN1C2=NC3=4
InChiKey: KNGXEAMYHAUVNK-LLVKDONJSA-N
InChi: InChI=1S/C20H21FN6O3/c1-11-9-29-15-8-27-16-14(6-23-27)18(28)25-20(2,3)10-30-19-12(4-13(21)5-22-19)7-26(11)17(15)24-16/h4-6,8,11H,7,9-10H2,1-3H3,(H,25,28)/t11-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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