CCR1 antagonist 9

Catalog No. Size PriceQuantity
M24016-C Contact for quotation $100Unavailable


CCR1 antagonist 9 is a potent and selective CCR1 antagonist with an IC50 of 6.8 nM in calcium flux assay.

Product information

CAS Number: 1220026-26-5

Molecular Weight: 425.44

Formula: C20H16FN5O3S

Chemical Name: 1-(4-fluorophenyl)-N-[(2-methanesulfonylpyridin-4-yl)methyl]-1H-pyrazolo[3,4-c]pyridine-4-carboxamide

Smiles: CS(=O)(=O)C1=CC(CNC(=O)C2=CN=CC3=C2C=NN3C2C=CC(F)=CC=2)=CC=N1


InChi: InChI=1S/C20H16FN5O3S/c1-30(28,29)19-8-13(6-7-23-19)9-24-20(27)17-10-22-12-18-16(17)11-25-26(18)15-4-2-14(21)3-5-15/h2-8,10-12H,9H2,1H3,(H,24,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 83.33 mg/mL (195.87 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells with an IC50 of 28 nM. CCR1 antagonist 9 also blocks hERG with an IC50 of 30 μM.

Products are for research use only. Not for human use.

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