ARRY-382


Catalog No. Size PriceQuantity
M24061-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ARRY-382 is a potent, oral and highly selective inhibitor of CSF1R/c-Fms with an IC50 of 9 nM. ARRY-382 can be used for the research of advanced or metastatic cancers.

Product information

CAS Number: 1313407-95-2

Molecular Weight: 564.68

Formula: C32H36N8O2

Chemical Name: N-{3-cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]-1H-indazol-4-yl}-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide

Smiles: CN1CCN(CCOC2C=CN3C(=CN=C3C=2)C(=O)NC2=CC=CC3=C2C(=NN3CC2=CC=CC(C)=N2)C2CC2)CC1

InChiKey: JUPOTOIJLKDAPF-UHFFFAOYSA-N

InChi: InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 8.33 mg/mL (14.75 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ARRY-382 (1 µM) dramatically decreases the number of nurse-like cells (NLCs) compared to untreated cells.

Products are for research use only. Not for human use.

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