SGK1-IN-1


Catalog No. Size PriceQuantity
M24075-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

Product information

CAS Number: 1279829-87-6

Molecular Weight: 418.83

Formula: C17H12ClFN6O2S

Chemical Name: N-(4-{3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl}phenyl)-5-chloro-2-fluorobenzene-1-sulfonamide

Smiles: NC1NN=C2N=C(C=NC2=1)C1C=CC(=CC=1)NS(=O)(=O)C1=CC(Cl)=CC=C1F

InChiKey: DDKHTWASHUKHLD-UHFFFAOYSA-N

InChi: InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (119.38 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM.

Products are for research use only. Not for human use.

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