DYRKs-IN-2


Catalog No. Size PriceQuantity
M24120-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity.

Product information

CAS Number: 1386980-04-6

Molecular Weight: 632.16

Formula: C32H38ClN9O3

Chemical Name: N-{5-[(3-amino-1-phenylpropyl)carbamoyl]-2-chlorophenyl}-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}-7-oxo-7H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide

Smiles: CN1CCN(CCCNC2=NC3NC(=O)C(=CC=3C=N2)C(=O)NC2=CC(=CC=C2Cl)C(=O)NC(CCN)C2C=CC=CC=2)CC1

InChiKey: QJRRYVISMPFJOU-UHFFFAOYSA-N

InChi: InChI=1S/C32H38ClN9O3/c1-41-14-16-42(17-15-41)13-5-12-35-32-36-20-23-18-24(31(45)39-28(23)40-32)30(44)38-27-19-22(8-9-25(27)33)29(43)37-26(10-11-34)21-6-3-2-4-7-21/h2-4,6-9,18-20,26H,5,10-17,34H2,1H3,(H,37,43)(H,38,44)(H2,35,36,39,40,45)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DYRKs-IN-2 (Example 132) has an EC50 of 22.8 nM for SW620 cell line.

Products are for research use only. Not for human use.

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