Description
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM.
Product information
CAS Number: 244082-19-7
Molecular Weight: 1166.33
Formula: C52H71N13O14S2
Chemical Name: (4R,7S,10S,13S,19S,22S,25S,28S,31R)-31-amino-13-benzyl-10,25,28-tris[(1R)-1-hydroxyethyl]-22-[(1H-imidazol-5-yl)methyl]-19-[(1H-indol-3-yl)methyl]-7-(2-methylpropyl)-6,9,12,15,18,21,24,27,30-nonaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29-nonaazacyclodotriacontane-4-carboxylic acid
Smiles: CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CSSC[C@H](NC1=O)C(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
InChiKey: YAJDFZGRPZQVJN-JIYQNHPRSA-N
InChi: InChI=1S/C52H71N13O14S2/c1-25(2)15-35-46(72)62-39(52(78)79)23-81-80-22-33(53)44(70)63-43(28(5)68)51(77)65-42(27(4)67)50(76)61-38(18-31-20-54-24-57-31)47(73)59-37(17-30-19-55-34-14-10-9-13-32(30)34)45(71)56-21-40(69)58-36(16-29-11-7-6-8-12-29)48(74)64-41(26(3)66)49(75)60-35/h6-14,19-20,24-28,33,35-39,41-43,55,66-68H,15-18,21-23,53H2,1-5H3,(H,54,57)(H,56,71)(H,58,69)(H,59,73)(H,60,75)(H,61,76)(H,62,72)(H,63,70)(H,64,74)(H,65,77)(H,78,79)/t26-,27-,28-,33+,35+,36+,37+,38+,39+,41+,42+,43+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CTTHWGFTLC, CYCLIC inhibits endothelial and tumor cell migration in vitro.
In Vivo:
CTTHWGFTLC, CYCLIC inhibits tumor progression in vivo, in mouse models.
Products are for research use only. Not for human use.
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