Description
AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1.
Product information
CAS Number: 1295514-91-8
Molecular Weight: 505.58
Formula: C25H34F3N7O
Chemical Name: (5R)-5-methyl-4-(4-{1-[2-(pyrrolidin-1-yl)ethyl]-4-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl}piperidin-1-yl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-7-one
Smiles: C[C@@H]1CC(=O)NC2=NC=NC(=C21)N1CCC(CC1)C1=NC(CCC(F)(F)F)=CN1CCN1CCCC1
InChiKey: QRULDXBXPXGMQS-QGZVFWFLSA-N
InChi: InChI=1S/C25H34F3N7O/c1-17-14-20(36)32-22-21(17)24(30-16-29-22)34-10-5-18(6-11-34)23-31-19(4-7-25(26,27)28)15-35(23)13-12-33-8-2-3-9-33/h15-18H,2-14H2,1H3,(H,29,30,32,36)/t17-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β with IC50s of 0.399, 0.084, 3.98, 0.568, and 0.092 μM, respectively.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
