Description
JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms.
Product information
CAS Number: 1036241-36-7
Molecular Weight: 345.78
Formula: C20H12ClN3O
Chemical Name: 3-chloro-4-{8,12,14-triazatetracyclo[8.6.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2,4,6,8,10,12,15-octaen-9-yl}phenol
Smiles: OC1=CC(Cl)=C(C=C1)C1=NC2=CC=CC=C2C2C=CNC3=NC=C1C=23
InChiKey: JBHMPWHPXOOFNL-UHFFFAOYSA-N
InChi: InChI=1S/C20H12ClN3O/c21-16-9-11(25)5-6-14(16)19-15-10-23-20-18(15)13(7-8-22-20)12-3-1-2-4-17(12)24-19/h1-10,25H,(H,22,23)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies.
Products are for research use only. Not for human use.
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