Description
KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.
Product information
CAS Number: 1228439-36-8
Molecular Weight: 415.50
Formula: C22H25NO5S
Chemical Name: benzyl 1-acetyl-2-[(4-methanesulfonylphenyl)methyl]pyrrolidine-2-carboxylate
Smiles: CC(=O)N1CCCC1(CC1C=CC(=CC=1)S(C)(=O)=O)C(=O)OCC1C=CC=CC=1
InChiKey: XFXZWVGQXNFWDE-UHFFFAOYSA-N
InChi: InChI=1S/C22H25NO5S/c1-17(24)23-14-6-13-22(23,21(25)28-16-19-7-4-3-5-8-19)15-18-9-11-20(12-10-18)29(2,26)27/h3-5,7-12H,6,13-16H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (601.68 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%.
In Vivo:
KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats.
Products are for research use only. Not for human use.
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