Description
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria.
Product information
CAS Number: 425629-94-3
Molecular Weight: 297.76
Formula: C13H12ClNO3S
Chemical Name: ethyl 2-[(4-chlorophenyl)imino]-4-hydroxy-2,5-dihydrothiophene-3-carboxylate
Smiles: CCOC(=O)C1=C(O)CSC1=NC1C=CC(Cl)=CC=1
InChiKey: APZUOZADGNBHOB-QINSGFPZSA-N
InChi: InChI=1S/C13H12ClNO3S/c1-2-18-13(17)11-10(16)7-19-12(11)15-9-5-3-8(14)4-6-9/h3-6,16H,2,7H2,1H3/b15-12-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 12.5 mg/mL (41.98 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality. PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 µM) over hDHODH (IC50>50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 µM, respectively in whole cell assays.
Products are for research use only. Not for human use.
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