AF64394


Catalog No. Size PriceQuantity
M24876-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

Product information

CAS Number: 1637300-25-4

Molecular Weight: 393.87

Formula: C21H20ClN5O

Chemical Name: N-{[4-chloro-2-(propan-2-yloxy)phenyl]methyl}-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Smiles: CC(C)OC1=CC(Cl)=CC=C1CNC1=CC(=NC2=NC=NN12)C1C=CC=CC=1

InChiKey: WBYNZQXAAWPAGR-UHFFFAOYSA-N

InChi: InChI=1S/C21H20ClN5O/c1-14(2)28-19-10-17(22)9-8-16(19)12-23-20-11-18(15-6-4-3-5-7-15)26-21-24-13-25-27(20)21/h3-11,13-14,23H,12H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (317.36 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization.

Products are for research use only. Not for human use.

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