Herniarin


Catalog No. Size PriceQuantity
M24880-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.

Product information

CAS Number: 531-59-9

Molecular Weight: 176.17

Formula: C10H8O3

Chemical Name: 7-methoxy-2H-chromen-2-one

Smiles: COC1=CC=C2C=CC(=O)OC2=C1

InChiKey: LIIALPBMIOVAHH-UHFFFAOYSA-N

InChi: InChI=1S/C10H8O3/c1-12-8-4-2-7-3-5-10(11)13-9(7)6-8/h2-6H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (709.54 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 µM. Herniarin (100 µM) also induces apoptosis in MCF-7 cells. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 µg/mL cisplatin, Herniarin (80 µg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation.

Products are for research use only. Not for human use.

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