Description
SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice.
Product information
CAS Number: 83861-02-3
Molecular Weight: 384.43
Formula: C21H24N2O5
Chemical Name: (2S)-2-{[(1S)-1-[(2-carboxyethyl)carbamoyl]-2-phenylethyl]amino}-3-phenylpropanoic acid
Smiles: OC(=O)CCNC(=O)[C@H](CC1C=CC=CC=1)N[C@@H](CC1C=CC=CC=1)C(O)=O
InChiKey: WOVRTBFSWOVRST-ROUUACIJSA-N
InChi: InChI=1S/C21H24N2O5/c24-19(25)11-12-22-20(26)17(13-15-7-3-1-4-8-15)23-18(21(27)28)14-16-9-5-2-6-10-16/h1-10,17-18,23H,11-14H2,(H,22,26)(H,24,25)(H,27,28)/t17-,18-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (325.16 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM.
In Vivo:
SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice.
Products are for research use only. Not for human use.
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