Description
Esonarimod (KE-298) is an antirheumatic agent.
Product information
CAS Number: 101973-77-7
Molecular Weight: 280.34
Formula: C14H16O4S
Chemical Name: 2-[(acetylsulfanyl)methyl]-4-(4-methylphenyl)-4-oxobutanoic acid
Smiles: CC(=O)SCC(CC(=O)C1C=CC(C)=CC=1)C(O)=O
InChiKey: YRSSFEUQNAXQMX-UHFFFAOYSA-N
InChi: InChI=1S/C14H16O4S/c1-9-3-5-11(6-4-9)13(16)7-12(14(17)18)8-19-10(2)15/h3-6,12H,7-8H2,1-2H3,(H,17,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (356.71 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC50 of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells.
In Vivo:
After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found.
Products are for research use only. Not for human use.
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