Description
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 858126-78-0
Molecular Weight: 528.47
Formula: C21H28N4O12
Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-[(2,4-dinitrophenyl)amino]-3,6,9,12-tetraoxapentadecan-15-oate
Smiles: [O-][N+](=O)C1=CC(=CC=C1NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)[N+]([O-])=O
InChiKey: OZBOCCBKQAMCSA-UHFFFAOYSA-N
InChi: InChI=1S/C21H28N4O12/c26-19-3-4-20(27)23(19)37-21(28)5-7-33-9-11-35-13-14-36-12-10-34-8-6-22-17-2-1-16(24(29)30)15-18(17)25(31)32/h1-2,15,22H,3-14H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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