Description
TAMRA-PEG4-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 1225057-68-0
Molecular Weight: 643.73
Formula: C36H41N3O8
Chemical Name: 2-[6-(dimethylamino)-3-(dimethyliminiumyl)-3H-xanthen-9-yl]-5-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)carbamoyl]benzoate
Smiles: CN(C)C1=CC2OC3=CC(C=CC3=C(C3=CC=C(C=C3C([O-])=O)C(=O)NCCOCCOCCOCCOCC#C)C=2C=C1)=[N+](C)C
InChiKey: WQEIEHQRZQLUSE-UHFFFAOYSA-N
InChi: InChI=1S/C36H41N3O8/c1-6-14-43-16-18-45-20-21-46-19-17-44-15-13-37-35(40)25-7-10-28(31(22-25)36(41)42)34-29-11-8-26(38(2)3)23-32(29)47-33-24-27(39(4)5)9-12-30(33)34/h1,7-12,22-24H,13-21H2,2-5H3,(H-,37,40,41,42)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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