Description
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.
Product information
CAS Number: 958204-56-3
Molecular Weight: 1159.23
Formula: C38H85F3N24O14
Chemical Name: hexakis(2-amino-5-[(diaminomethylidene)amino]pentanoic acid); trifluoroacetic acid
Smiles: NC(N)=NCCCC(N)C(O)=O.NC(N)=NCCCC(N)C(O)=O.NC(N)=NCCCC(N)C(O)=O.NC(N)=NCCCC(N)C(O)=O.NC(N)=NCCCC(N)C(O)=O.NC(N)=NCCCC(N)C(O)=O.OC(=O)C(F)(F)F
InChiKey: CLXOAXAOLSYNEV-UHFFFAOYSA-N
InChi: InChI=1S/6C6H14N4O2.C2HF3O2/c6*7-4(5(11)12)2-1-3-10-6(8)9;3-2(4,5)1(6)7/h6*4H,1-3,7H2,(H,11,12)(H4,8,9,10);(H,6,7)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
In Vivo:
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
Products are for research use only. Not for human use.
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