Description
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.
Product information
CAS Number: 2412923-79-4
Molecular Weight: 758.86
Formula: C42H46N8O6
Chemical Name: N-(4-aminophenyl)-4-{4-[4-(4-{[(11S)-5-methoxy-2-oxo-1,9-diazatricyclo[9.4.0.0³,⁸]pentadeca-3(8),4,6-trien-6-yl]oxy}butanamido)-1-methyl-1H-pyrrole-2-amido]phenyl}-1-methyl-1H-pyrrole-2-carboxamide
Smiles: COC1=CC2=C(C=C1OCCCC(=O)NC1=CN(C)C(=C1)C(=O)NC1C=CC(=CC=1)C1C=C(C(=O)NC3C=CC(N)=CC=3)N(C)C=1)NC[C@@H]1CCCCN1C2=O
InChiKey: IRTLLBFDZDUFNC-YTTGMZPUSA-N
InChi: InChI=1S/C42H46N8O6/c1-48-24-27(19-35(48)40(52)47-30-15-11-28(43)12-16-30)26-9-13-29(14-10-26)46-41(53)36-20-31(25-49(36)2)45-39(51)8-6-18-56-38-22-34-33(21-37(38)55-3)42(54)50-17-5-4-7-32(50)23-44-34/h9-16,19-22,24-25,32,44H,4-8,17-18,23,43H2,1-3H3,(H,45,51)(H,46,53)(H,47,52)/t32-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined.
Products are for research use only. Not for human use.
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