Katacalcin

Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide.

Product information

CAS Number: 85916-47-8

Molecular Weight: 2436.60

Formula: C97H154N34O36S2

Chemical Name: 4-{2-[2-(2-{2-[2-(2-amino-3-carboxypropanamido)-4-(methylsulfanyl)butanamido]-3-hydroxypropanamido}-3-hydroxypropanamido)-3-carboxypropanamido]-4-methylpentanamido}-4-[(4-carbamimidamido-1-{[1-({1-[(5-carbamimidamido-1-{2-[(1-{[1-({1-[(1-{2-[(3-carbamoyl-1-{[2-carbamoyl-1-({1-[(2-carbamoyl-1-carboxyethyl)carbamoyl]ethyl}carbamoyl)ethyl]carbamoyl}propyl)carbamoyl]pyrrolidin-1-yl}-4-(methylsulfanyl)-1-oxobutan-2-yl)carbamoyl]-2-hydroxyethyl}carbamoyl)-2-methylpropyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl)carbamoyl]pyrrolidin-1-yl}-1-oxopentan-2-yl)carbamoyl]-2-(1H-imidazol-4-yl)ethyl}carbamoyl)-2-carboxyethyl]carbamoyl}butyl)carbamoyl]butanoic acid

Smiles: CC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC1=CNC=N1)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CC1=CNC=N1)NC(=O)C(CC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC(N)=O)C(O)=O

InChiKey: UYPZXUIXSSDJPM-UHFFFAOYSA-N

InChi: InChI=1S/C97H154N34O36S2/c1-43(2)28-55(119-84(155)60(35-73(144)145)123-88(159)62(38-132)127-89(160)63(39-133)126-80(151)52(20-26-168-6)113-76(147)48(98)31-71(140)141)82(153)115-51(17-19-70(138)139)78(149)114-49(12-8-22-108-96(102)103)77(148)122-59(34-72(142)143)85(156)120-56(29-46-36-106-41-110-46)83(154)117-53(13-9-23-109-97(104)105)93(164)130-24-11-15-66(130)91(162)124-57(30-47-37-107-42-111-47)86(157)129-74(44(3)4)92(163)128-64(40-134)87(158)118-54(21-27-169-7)94(165)131-25-10-14-65(131)90(161)116-50(16-18-67(99)135)79(150)121-58(32-68(100)136)81(152)112-45(5)75(146)125-61(95(166)167)33-69(101)137/h36-37,41-45,48-66,74,132-134H,8-35,38-40,98H2,1-7H3,(H2,99,135)(H2,100,136)(H2,101,137)(H,106,110)(H,107,111)(H,112,152)(H,113,147)(H,114,149)(H,115,153)(H,116,161)(H,117,154)(H,118,158)(H,119,155)(H,120,156)(H,121,150)(H,122,148)(H,123,159)(H,124,162)(H,125,146)(H,126,151)(H,127,160)(H,128,163)(H,129,157)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)(H4,102,103,108)(H4,104,105,109)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14+ PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14+ PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways.

Products are for research use only. Not for human use.