EPAC 5376753


Catalog No. Size PriceQuantity
M26285-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

Product information

CAS Number: 302826-61-5

Molecular Weight: 367.21

Formula: C15H8Cl2N2O3S

Chemical Name: 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione

Smiles: O=C1NC(=S)NC(=O)C1=CC1=CC=C(O1)C1=CC=C(Cl)C=C1Cl

InChiKey: QQAOFKJHOUFHKI-UHFFFAOYSA-N

InChi: InChI=1S/C15H8Cl2N2O3S/c16-7-1-3-9(11(17)5-7)12-4-2-8(22-12)6-10-13(20)18-15(23)19-14(10)21/h1-6H,(H2,18,19,20,21,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts.

Products are for research use only. Not for human use.

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