EC330


Catalog No. Size PriceQuantity
M26309-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EC330 is a leukemia inhibitory factor (LIF) inhibitor.

Product information

CAS Number: 2016795-77-8

Molecular Weight: 462.57

Formula: C30H32F2O2

Chemical Name: (1S,3aS,3bS,10R,11aS)-10-(4-cyclopropylphenyl)-1-(1,1-difluoroprop-2-yn-1-yl)-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

Smiles: C[C@]12C[C@@H](C3[C@@H](CCC4=CC(=O)CCC4=3)[C@@H]1CC[C@@]2(O)C(F)(F)C#C)C1C=CC(=CC=1)C1CC1

InChiKey: OWPPSPZDYGHPAN-GCNJZUOMSA-N

InChi: InChI=1S/C30H32F2O2/c1-3-30(31,32)29(34)15-14-26-24-12-10-21-16-22(33)11-13-23(21)27(24)25(17-28(26,29)2)20-8-6-19(7-9-20)18-4-5-18/h1,6-9,16,18,24-26,34H,4-5,10-15,17H2,2H3/t24-,25+,26-,28-,29-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 20 mg/mL (43.24 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EC330 shows marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. EC330 further shows cytoskeletal disruption and targeting cancer-associated fibroblasts (CAFs) through inhibition of alpha-SMA but not beta-tubulin.

In Vivo:

EC330 treatment (0.1, 0.5 and 2.5 mg/kg) dose dependently reduces tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models as well as MDA-MB-231 PDX models. EC330 exhibits no reactivity towards thiol-cysteine residues, no off target binding to major receptors, kinases or ion channels. EC330 is orally bioavailable and found to be safe and tolerable in toxicity studies.

Products are for research use only. Not for human use.

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