ABC99


Catalog No. Size PriceQuantity
M26369-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM.

Product information

CAS Number: 2331255-53-7

Molecular Weight: 456.88

Formula: C22H21ClN4O5

Chemical Name: 7-[(4-chlorophenyl)methyl]-1,3-dioxo-octahydroimidazo[1,5-a]pyrazin-2-yl 3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate

Smiles: O=C1N(OC(=O)N2CCOC3=CC=CC=C23)C(=O)C2CN(CC3C=CC(Cl)=CC=3)CCN12

InChiKey: OZPZCETZTBBQBO-UHFFFAOYSA-N

InChi: InChI=1S/C22H21ClN4O5/c23-16-7-5-15(6-8-16)13-24-9-10-25-18(14-24)20(28)27(21(25)29)32-22(30)26-11-12-31-19-4-2-1-3-17(19)26/h1-8,18H,9-14H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner. ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.

Products are for research use only. Not for human use.

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