PF-07104091


Catalog No. Size PriceQuantity
M26627-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PF-07104091 is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2).

Product information

CAS Number: 2460249-19-6

Molecular Weight: 404.46

Formula: C19H28N6O4

Chemical Name: (1R,3S)-3-{3-[3-(methoxymethyl)-1-methyl-1H-pyrazole-5-amido]-1H-pyrazol-5-yl}cyclopentyl N-(propan-2-yl)carbamate

Smiles: CC(C)NC(=O)O[C@H]1C[C@H](CC1)C1=CC(NC(=O)C2=CC(COC)=NN2C)=NN1

InChiKey: MTNBRBDFNSGQKB-GXTWGEPZSA-N

InChi: InChI=1S/C19H28N6O4/c1-11(2)20-19(27)29-14-6-5-12(7-14)15-9-17(23-22-15)21-18(26)16-8-13(10-28-4)24-25(16)3/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,20,27)(H2,21,22,23,26)/t12-,14+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PF-07104091 (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM, respectively.

Products are for research use only. Not for human use.

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