Description
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability.
Product information
CAS Number: 2097938-74-2
Molecular Weight: 644.46
Formula: C28H26N2O12P2
Chemical Name: {4-[(2-{4-[(4-phenoxyphenyl)carbamoyl]phenoxy}acetamido)methyl]-2-(phosphonooxy)phenoxy}phosphonic acid
Smiles: OP(O)(=O)OC1=CC(CNC(=O)COC2C=CC(=CC=2)C(=O)NC2C=CC(=CC=2)OC2C=CC=CC=2)=CC=C1OP(O)(O)=O
InChiKey: LJGIDZSIOSYQMR-UHFFFAOYSA-N
InChi: InChI=1S/C28H26N2O12P2/c31-27(29-17-19-6-15-25(41-43(33,34)35)26(16-19)42-44(36,37)38)18-39-22-11-7-20(8-12-22)28(32)30-21-9-13-24(14-10-21)40-23-4-2-1-3-5-23/h1-16H,17-18H2,(H,29,31)(H,30,32)(H2,33,34,35)(H2,36,37,38)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (77.58 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM). Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells.
Products are for research use only. Not for human use.
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